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5-Amino-1MQ (NNMT Inhibitor)

5-Amino-1-methylquinolinium (5-Amino-1MQ, CAS 42464-96-0) is a small-molecule quaternary ammonium compound studied as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT converts nicotinamide (a NAD+ precursor) into 1-methylnicotinamide; blocking it in research models can shift cellular NAD+ and methylation balance.

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Product Specifications

  • Format: 30mg x 60 tablets
  • Class: NNMT inhibitor
  • CAS: 42464-96-0
  • Documentation available
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Research use only. Not for human or animal use.

Research Summary

  • Cell-culture studies in 3T3-L1 adipocytes (10-30 μM) report 1.2-1.6x increases in cellular NAD+.
  • Rodent studies on diet-induced obese (DIO) mice reported reductions in white-adipose mass and adipocyte size with 11-day dosing.
  • Aged-mouse studies have examined effects on grip strength and endurance in muscle research.
  • No human clinical trials have been published — all current data are from cell models and rodent studies.

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Important Disclaimer

This page is for educational and informational purposes only. This product is a research chemical sold for laboratory use only. Not intended for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider. These statements have not been evaluated by the FDA.